降雨入渗对非饱和土体边坡稳定性影响及治理对策

为研究降雨入渗对非饱和土体边坡稳定性影响，基于饱和—非饱和渗流理论，分析了降雨入渗条件下边坡内部渗流场变化及其对边坡稳定性的影响。研究表明：①降雨入渗是饱和—非饱和过程，其内部体积含水率随降雨持续时间的变化而发生动态改变，在降雨初期，土体处于非饱和状态，黏聚力随着含水率的增大而增大，内摩擦角变化幅度较小，总体呈下降趋势，基质吸力增强，安全系数升高，对边坡稳定性有利；②随着降雨持续，孔隙水压力由负变正，黏聚力和内摩擦角随着含水率的增大而减小，基质吸力减弱，边坡稳定性降低；③降雨入渗终态过程为内部水位线升高，动静水压增加，土体有效重度降低，土体发生软化，力学强度参数降低，边坡稳定性随之降低，土体渗透系数与边坡安全系数总体成反比关系。在上述分析的基础上，结合土质边坡实例，应用强度折减法，分析了降雨入渗状态下边坡潜在滑动面、峰值位移随降雨持续时间的变化规律，认为降雨初期潜在滑动面由浅入深，峰值位移不断增大；降雨停止后，土体内部应力重新分布，土体由饱和转为非饱和，潜在滑动面、峰值位移发生逆变化。为防止降雨条件下边坡发生失稳破坏，针对性地提出了土质边坡治理建议，为非饱和土体边坡综合治理提供了有益参考。     

Spatiotemporal variations in soil CO2 fluxes under a winter wheat-summer maize cropping system in the North China Plain

Nutrient Cycling in Agroecosystems - Most studies on soil CO2 fluxes focus on the upper soil layers (i.e., 0–200 mm); however, there is a lack of investigation into soil layers below...     

Collection efficiency of liquid‐based samplers for fungi in indoor air

This study assessed the collection efficiency (CE) of two popularly used sampling devices (BioSampler and Coriolis sampler) for fungal aerosols. Phosphate‐buffered saline (PBS) supplemented with or without surfactant (Tween‐20, Tween‐80, or Triton X‐100) and antifoam agent was prepared and used as collection liquids. The agar impactor (BioStage) was simultaneously operated with liquid‐based samplers to collect fungi from seven sites located at a university building, public library, and animal farming. Fungal concentrations determined by liquid samplers were divided by those by BioStage, and the ratio values represented CE. Results indicate that the CE of BioSampler was superior to that of Coriolis (P = 0.0001) and the PBS containing surfactant collected fungi better than that without surfactant (P < 0.0001), whereas antifoam agent showed no influence (P = 0.8). Moreover, fungal concentrations determined by BioSampler with surfactant‐added PBS were statistically indifferent from those by BioStage (P > 0.05) with a Spearman correlation coefficient of 0.81‐0.83 (P < 0.01). In addition to sampler and collection liquid, sampling location was also identified as a significant CE factor (P = 0.006), implying potential influences by fungal genera in the studied fields. Overall, BioSampler with surfactant‐supplemented PBS (eg, Triton X‐100) is recommended considering the great CE and compatibility with a variety of analytical assays.     

Discovery of Affinity-Based Probes for Btk Occupancy Assays

Bruton's tyrosine kinase (Btk) is an attractive target for the treatment of a wide array of B-cell malignancies and autoimmune diseases. Small-molecule covalent irreversible Btk inhibitors targeting Cys481 have been developed for the treatment of such diseases. In clinical trials, probe molecules are required in occupancy studies to measure the level of engagement of the protein by these covalent irreversible inhibitors. The result of this pharmacodynamic (PD) activity provides guidance for appropriate dosage selection to optimize inhibition of the drug target and correlation of target inhibition with disease treatment efficacy. This information is crucial for successful evaluation of drug candidates in clinical trials. Based on the pyridine carboxamide scaffold of a novel solvent-accessible pocket (SAP) series of covalent irreversible Btk inhibitors, we successfully developed a potent and selective affinity-based biotinylated probe 12 (2-[(4-{4-[5-(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido}-3,6,9,12-tetraoxapentadecan-15-amido)pentanoyl]piperazine-1-carbonyl}phenyl)amino]-6-[1-(prop-2-enoyl)piperidin-4-yl]pyridine-3-carboxamide). Compound 12 has been used in Btk occupancy assays for preclinical studies to determine the therapeutic efficacy of Btk inhibition in two mouse lupus models driven by TLR7 activation and type I interferon.     

Ti-6Al-4V电弧熔丝增材轧制复合制造的有限元模拟

增材制造过程中由于在凝固及随后的冷却阶段易产生残余应力,从而影响部件的成形和使用。在增材过程中引入轧制工序,可望降低宏观残余应力,从而降低部件的变形。本文通过建立Ti-6Al-4V钛合金电弧熔丝增材与层间轧制复合成形过程的有限元模型,研究圆柱形轧辊条件下不同压下量对部件温度、应力、应变及残余应力分布的影响规律。结果表明,层间轧制可显著降低沉积层金属中的残余宏观应力；同时降低对基板的整体应力。采用圆柱形轧辊并增加压下量可显著降低宏观残余应力,还可以通过塑性变形改变材料的微观组织,提高材料性能,为复合增材工艺的优化指明了方向。     

The Marginal Density of a TMA(1) Process

This note reconsiders the marginal density of a threshold moving average process and proposes a simple yet effective numerical algorithm to implement that by solving an associated integral equation. This algorithm can also be applied to calculate stationary probability density or distribution functions of a few other types of nonlinear stationary stochastic processes numerically.     

High-Tg porous polyimide films with low dielectric constant derived from spiro-(adamantane-2,9′(2′,7′-diamino)-fluorene)

Porous polyimide (PI) films with low dielectric constants and excellent thermal properties have been a pressing demand for the next generation of high-performance, miniature, and ultrathin microelectronic devices. A series of novel porous PI films containing fluorenyl-adamantane groups were prepared successfully via thermolysis of poly(ethylene glycol) (PEG) added in the PI matrix. The cross-sectional morphologies of porous PI films showed closed pores with diameters ranging from 135 to 158 nm, which were uniform and regular in shape without interconnectivity. These porous PI films exhibited excellent thermal properties with a glass-transition temperature at 376 °C whereas the 5% weight loss temperature in air excess of 405 °C due to enhanced rigidity afforded by fluorenyl-adamantane groups. Accompanied by thermolysis content of PEG increasing from 0 to 20 wt %, the density of porous PI films decreased, and the corresponding porosity grew significantly from 0 to 11.48%. Depending on porosity, the dielectric constant and dielectric loss of porous PI films significantly declined from 2.89 to 2.37 and from 0.050 to 0.021, respectively. These excellent properties benefit the as-prepared porous PI films for application as interlayer dielectrics, integrated circuit chips, or multichip modules in microelectronic fields. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47313.     

四川盆地上三叠统划分对比研究

四川盆地上三叠统对比长期存在混乱，给盆地整体评价带来困难。通过岩石地层、地震地层、事件地层及高分辨率旋回地层等多种方法讨论了须家河组与香溪群各岩性段的对比关系，得出了全盆地上三叠统的对比关系；指出须四段底可近似看成等时界面；须家河组下部地层自西向东、向南逐层超覆在雷口坡组之上，上部地层在盆地西北部自东南向西北方向剥蚀层位渐次变老。文章建议四川盆地上三叠统废除“香溪群”，统一使用“须家河组”，以利于对全盆地上三叠统进行油气资源整体评价与深化研究。     

强捻棉纱针织产品的性能研究

通过对强捻棉纱针织产品进行服用性能测试，得出强捻纱织物具有良好的服用性能。